Here is page 21 of RFC 2822. Emphasis is mine.
RFC 2822 Internet Message Format April 2001 for delivery. The origination date is intended to contain the date and time that the user queued the message, not the time when the user connected to the network to send the message.) 3.6.2. Originator fields The originator fields of a message consist of the from field, the sender field (when applicable), and optionally the reply-to field. The from field consists of the field name "From" and a comma-separated list of one or more mailbox specifications. If the from field contains more than one mailbox specification in the mailbox-list, then the sender field, containing the field name "Sender" and a single mailbox specification, MUST appear in the message. In either case, an optional reply-to field MAY also be included, which contains the field name "Reply-To" and a comma-separated list of one or more addresses. from = "From:" mailbox-list CRLF sender = "Sender:" mailbox CRLF reply-to = "Reply-To:" address-list CRLF The originator fields indicate the mailbox(es) of the source of the message. The "From:" field specifies the author(s) of the message, that is, the mailbox(es) of the person(s) or system(s) responsible for the writing of the message. The "Sender:" field specifies the mailbox of the agent responsible for the actual transmission of the message. For example, if a secretary were to send a message for another person, the mailbox of the secretary would appear in the "Sender:" field and the mailbox of the actual author would appear in the "From:" field. If the originator of the message can be indicated by a single mailbox and the author and transmitter are identical, the "Sender:" field SHOULD NOT be used. Otherwise, both fields SHOULD appear. The originator fields also provide the information required when replying to a message. When the "Reply-To:" field is present, it indicates the mailbox(es) to which the author of the message suggests that replies be sent. In the absence of the "Reply-To:" field, replies SHOULD by default be sent to the mailbox(es) specified in the "From:" field unless otherwise specified by the person composing the reply. In all cases, the "From:" field SHOULD NOT contain any mailbox that does not belong to the author(s) of the message. See also section 3.6.3 for more information on forming the destination addresses for a reply. Resnick Standards Track [Page 21]